Our group is interested in the development and application of the state-of-the-art metagenomic and metatranscriptomic approaches, analytical chemistry, stable isotope probing, microfluidics, and other emerging methods and technologies for improved understanding of microbially-mediated pollutants biodegradation, bioresource recovery, and antibiotic resistance.
1) Antimicrobial agents and their resistance genes in the urban waterways
Antimicrobial resistance is taken as one of the world's largest public health threats in this century. Environment plays an important role in the generation and spread of antibiotic resistance. To reduce the transmission of clinically relevant antibiotic resistance from environment to humans and thus maximize the lifespan of antibiotics as effective medicines, there is an urgent need for quantitative assessment of the health risk of environmentally occurred antibiotic resistance genes (ARGs). This project is to develop new metrics and model that can quantitatively assess the risks of ARGs, and further apply them to predict the comprehensive health risks of ARGs of key clinically-used antibiotics in urban waterways, including extended spectrum beta-lactamase (ESBL) and carbapenemase-coding genes.
Municipal Wastewater treatment plants (WWTPs) are the reservoirs of various antimicrobial agents and their resistance genes from diverse anthropogenic sources in urban environment. Our recent research shows that WWTPs resistomes are Shaped by Bacterial Composition, Genetic Exchange, and Upregulated Expression in the Effluent Microbiomes (Ju F et al., 2019).
2) Microbial Community AssemblyPatterns and Processes in Engineered Ecosystems.
To be updated
3) Environmental Biodegradation and DisinfectionByproducts of Non-Antibiotic Pharmaceuticals
To be updated